The synopsis goes something like this ...
Beverley Hills 90210 meets The Howling when brother and sister Ellie (Ricci) and Jimmy (Eisenberg) are attacked one night by a werewolf on Mullholland Drive. It soon becomes apparent that what they were dealing with was a werewolf after the pair themselves begin to change - such as having an increased desire for meat. Jimmy's new animal magnetism also attracts the captain of the school wrestling team, and closet homosexual, Bo (Milo Ventimiglia). Both siblings are further hunted by the original werewolves, Ellie's boyfriend Jake (Jackson) and his obsessed jilted ex, Joanie (Judy Greer).